2007-07-30
Partner search - Bioinformatics - FP7- Health
An international consortium of 12 partners specialised in neurosciences is seeking for a supplementary partner in bioinformatics. We are looking for a bioinformatician team interested in our project and motivated to become full partner in this challenging project.
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PARTNER SEARCH - HEALTH
a) Information on the call
HEALTH-2007-2.2.1-7: Restorative approaches for therapy of neurodegenerative diseases. Research should focus on basic mechanisms of brain plasticity and brain repair inneurodegenerative diseases and translate this knowledge into new neuroprotective orrestorative therapeutic approaches.
Funding scheme: Collaborative projects (Small ormedium-scale focused research projects with maximum EC contribution of €6,000,000/project).
b) Title of the project
Amyotrophic Lateral Sclerosis - Pathogenic Mechanisms and Therapeutical Approach
c) Concept of the project
ALS being a multifactorial disease in which motor-neurons die, the concept is that neuroprotection of motor-neurons can only be achieved with drugs having at once different neuroprotective capacities. In this work we will use in separate workpackages (WP) “proof of concept” and “preclinical studies”. The proof of concept having the goal to elucidate the mechanism of the disease by using Gemals as an investigation tool (WP1, WP2 and WP3) and translational studies to develop prerequisites for clinical studies (WP4 and WP5).
d) What we look for
The first WP deals with the benchmarking of ALS models, the second focuses on studies on mechanisms involved in cell damage and the third one focuses on the pharmacological testing of compounds, the fourth will be on bioinformatics and the fifth deals with industrial application.
The translational development from our basic science WPs can only be effective if all the data collected within those basic sciences packages can be encoded in a “friendly users” database which will be the core of WP4.
So for instance in WP1 many images (light microscopy, electron microscopy and magnetic resonance imaging) will be collected. The encoding of them with appropriate caption and software will be of great help to follow the progression of the disease (with or without neuroprotective drugs) from several points of view.
Besides being a very important chapter of the project, design of database and of adapted software by mathematicians/computer specialists will add an important interdisciplinary added value.
Our international consortium is made of 12 partners specialised in neurosciences is seeking for a supplementary partner in bioinformatics. We are looking for a bioinformatician team interested in our project and motivated to become full partner in this challenging project.
d) What we offer
The project is in an advanced phase of writing and it appeared than an important added value would be to have a work package dedicated to the design of software and database useful for the translation of data from basic science to preclinical study.
If our project is scored as scientifically excellent and selected it is expected that the new “bioinformatics” partner will benefit of one postdoc (4 years), one (maybe two) specialised technicians (4 years) and running expenses of at least 20.000 Euros/year. In addition he will share the intellectual properties and increases its scientific visibility and production.
e) Contact details
Please contact Professor Roland Pochet at the following address: rpochet@ulb.ac.be
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